Initial antibiotic therapy of neonatal sepsis

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Empirical choice of antibiotic therapy in sepsis.

528 Journal of the Royal College of Physicians of London Vol. 34 No. 6 November/December 2000 40 Lefering R, Neugebauer EAM. Steroid controversy in septic shock: a metaanalysis. Crit Care Med 1995;23: 1294–303. 41 Bollaert PE, Charpentier C, Levy B, Debouverie M, et al. Reversal of late septic shock with supraphysiologic doses of hydrocortisone. Crit Care Med 1998;26:645–50. 42 Briegel J, Forst...

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Neonatal Sepsis: An Update

Sepsis is the most common cause of neonatal mortality. As per National Neonatal-Perinatal Database (NNPD), 2002-2003, the incidence of neonatal sepsis in India was 30 per 1000 live births. Signs and symptoms of sepsis are nonspecific; therefore empirical antimicrobial therapy is promptly initiated after obtaining appropriate cultures. The early manifestations of neonatal sepsis are vague and il...

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Prognostic value of initial antithrombin levels in neonatal sepsis.

OBJECTIVES We determined whether initial antithrombin (AT) levels help in diagnosis and prognosis of neonatal sepsis. METHODS Sepsis was diagnosed according to clinical and laboratory findings and positive culture results in 34 of the 54 newborns who presented to the hospital with suspected sepsis. Between AT levels and hematological parameters (fibrinogen levels, prothrombin time (PT), activ...

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Medication Therapy for Early-Onset Neonatal Sepsis.

S sepsis is a common cause of morbidity and mortality in neonates. In a population-based surveillance study1 from 2005 to 2008, researchers estimated that 3300 cases of early-onset sepsis (EOS) occur in the United States each year, with 390 of these cases resulting in death. The risk is highest in preterm neonates, which account for 1570 of the 3300 cases and 360 deaths.1 Despite its prevalence...

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Use of Serial C-reactive Protein Measure-ments for Determination of the Length of Empiric Antibiotic Therapy in Suspected Neonatal Sepsis

Background: The management of neonatal sepsis especially in developing countries is problematic.  There is no single reliable marker of infection available at the present.  C-reactive protein (CRP) has long been used as a marker of infection. Serial measurements of CRP are recommended as a guide for duration of antibiotic therapy. Objective: To evaluate the serial CRP measurement as a guideline...

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ژورنال

عنوان ژورنال: Srpski arhiv za celokupno lekarstvo

سال: 2004

ISSN: 0370-8179,2406-0895

DOI: 10.2298/sarh04s1049j